Anti-Glomerular Basement Membrane Disease
Synonyms
Anti GBM Disease
Anti Glomerular Basement Membrane Disease
Anti-GBM Disease
Goodpasture Syndrome
Goodpasture's Syndrome
Goodpastures Syndrome
Lung Purpura with Nephritis
Syndrome, Goodpasture
Syndrome, Goodpasture's
An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.
See Also