Apoptoses, Extrinsic Pathway

Apoptoses, Intrinsic Pathway

Apoptosis, Extrinsic Pathway

Apoptosis, Intrinsic Pathway

Extrinsic Pathway Apoptoses

Extrinsic Pathway Apoptosis

Intrinsic Pathway Apoptoses

Intrinsic Pathway Apoptosis

Programmed Cell Death, Type I

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.