Calcineurin A

Calcineurin B

Phosphatase 3, Protein

Protein Phosphatase 2B

Protein Phosphatase 3

Protein Phosphatase 3 Catalytic Subunit

Protein Phosphatase 3 Regulatory Subunit

Protein Phosphatase-2B

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.