Complement Membrane Attack Complex
Synonyms
C 5b-9
C5b 8 poly C9
C5b-8-poly-C9
C5b-9
Complement Complex C5b 9
Complement Complex C5b-9
Complement Complex, Terminal
Complex, Terminal Complement
Cytolytic Terminal Complement Complex
Membrane Attack Complex
Terminal Complement Complex
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.