Complement Membrane Attack Complex


C 5b-9

C5b 8 poly C9



Complement Complex C5b 9

Complement Complex C5b-9

Complement Complex, Terminal

Complex, Terminal Complement

Cytolytic Terminal Complement Complex

Membrane Attack Complex

Terminal Complement Complex

A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.