Dideoxynucleosides
Synonyms
2',3' Dideoxynucleosides
2',3'-Dideoxynucleosides
Dideoxyribonucleosides
ddNus
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.