Discoidin Domain Receptors


DDR Proteins

Discoidin Domain Receptor

Proteins, DDR

Receptor, Discoidin Domain

Receptors, Discoidin Domain

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.