Endodermal Sinus Tumor


Endodermal Sinus Tumors

Tumor, Endodermal Sinus

Tumor, Yolk Sac

Tumors, Endodermal Sinus

Tumors, Yolk Sac

Yolk Sac Tumor

Yolk Sac Tumors

An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)