Filamins

Synonyms

1-Like Protein, Filamin

1-Like Proteins, Filamin

280 kDa Actin Binding Protein

280 kDa Actin-Binding Protein

Cs, Filamin

Filamin

Filamin 1

Filamin 1 Like Protein

Filamin 1-Like Protein

Filamin 1-Like Proteins

Filamin A

Filamin B

Filamin C

Filamin Cs

Merofilamin

Merofilamins

Protein, Filamin 1-Like

Proteins, Filamin 1-Like

alpha Filamin

alpha-Filamin

alpha-Filamins

beta Filamin

beta-Filamin

beta-Filamins

A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.