Heavy Chain Disease


Franklin Disease

Franklin's Disease

Franklins Disease

Heavy Chain Diseases

gamma Chain Disease

gamma-Chain Disease

gamma-Chain Diseases

mu Chain Disease

mu-Chain Disease

mu-Chain Diseases

A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.