Isocitrate Dehydrogenase


Dehydrogenase, Isocitrate

Dehydrogenase, NAD Isocitrate

Isocitrate Dehydrogenase (NAD+)

Isocitrate Dehydrogenase I

Isocitrate Dehydrogenase, NAD

Isocitrate Dehydrogenase-I

Isocitrate:NAD+ oxidoreductase (decarboxylating)

NAD Isocitrate Dehydrogenase

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC EC