Keratoderma, Palmoplantar, Diffuse


Keratosis Palmaris et Plantaris Familiaris

Syndrome, Thost-Unna

Syndrome, Unna-Thost

Thost Unna Syndrome

Thost-Unna Syndrome


Unna Thost Syndrome

Unna-Thost Syndrome

An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.