Methylmalonate-Semialdehyde Dehydrogenase (Acylating)
Synonyms
Dehydrogenase, MMSA
MMSA Dehydrogenase
MMSDH
Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.