Nitric Oxide


Endogenous Nitrate Vasodilator

Endothelium-Derived Nitric Oxide

Mononitrogen Monoxide

Monoxide, Mononitrogen

Monoxide, Nitrogen

Nitrate Vasodilator, Endogenous

Nitric Oxide, Endothelium Derived

Nitric Oxide, Endothelium-Derived

Nitrogen Monoxide

Nitrogen oxide (NO)

Oxide, Nitric

Vasodilator, Endogenous Nitrate

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.