Patched-1 Receptor
Synonyms
PTCH1 Protein
Patched 1 Protein
Patched 1 Receptor
Patched Homolog 1
Patched Homolog-1
Patched Receptor 1
Patched Receptor-1
Patched-1 Protein
Receptor, Patched-1
Receptor-1, Patched
A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.