Lymphocyte Pore Forming Protein
Lymphocyte Pore-Forming Protein
Pore-Forming Protein, Lymphocyte
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.