Hutchinson Gilford Progeria Syndrome

Hutchinson Gilford Syndrome

Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford Progeria Syndromes

Hutchinson-Gilford Syndrome

Progeria Syndrome, Hutchinson-Gilford

Progeria Syndromes, Hutchinson-Gilford

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.