LDL Receptors, Lipoprotein
Lipoprotein LDL Receptors
Low Density Lipoprotein Receptor
Low Density Lipoprotein Receptors
Receptors, Lipoprotein LDL
Receptors, Lipoprotein, LDL
Receptors, Low Density Lipoprotein
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.