Receptors, LDL


LDL Receptor

LDL Receptors

LDL Receptors, Lipoprotein

Lipoprotein LDL Receptors

Low Density Lipoprotein Receptor

Low Density Lipoprotein Receptors

Receptor, LDL

Receptors, Lipoprotein LDL

Receptors, Lipoprotein, LDL

Receptors, Low Density Lipoprotein

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.