Spleen Focus-Forming Viruses
Synonyms
Focus-Forming Virus, Spleen
Focus-Forming Viruses, Spleen
Friend spleen focus forming virus
Friend spleen focus-forming virus
Rauscher Spleen Focus-Forming Virus
SFFV
Spleen Focus Forming Viruses
Spleen Focus-Forming Virus
Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences.