Supranuclear Palsy, Progressive


Ophthalmoplegia, Progressive Supranuclear

Palsy, Progressive Supranuclear

Progressive Supranuclear Ophthalmoplegia

Progressive Supranuclear Palsies

Progressive Supranuclear Palsy

Richardson Syndrome

Richardson's Syndrome

Steele Richardson Olszewski Disease

Steele Richardson Olszewski Syndrome

Steele-Richardson-Olszewski Disease

Steele-Richardson-Olszewski Syndrome

Supranuclear Ophthalmoplegia, Progressive

Supranuclear Palsies, Progressive

Supranuclear Palsy, Progressive, 1

Syndrome, Richardson's

Syndrome, Steele-Richardson-Olszewski

A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)