Tumor Suppressor p53-Binding Protein 1
Tumor Protein p53 Binding Protein, 1
Tumor Protein p53-Binding Protein, 1
Tumor Suppressor p53 Binding Protein 1
A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.