von Willebrand Factor

Synonyms

Factor VIII Related Antigen

Factor VIII-Related Antigen

Factor VIIIR Ag

Factor VIIIR RCo

Factor VIIIR-Ag

Factor VIIIR-RCo

Plasma Factor VIII Complex

Ristocetin Cofactor

Ristocetin Willebrand Factor

Ristocetin-Willebrand Factor

von Willebrand Protein

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.