Amyotrophic Lateral Sclerosis


ALS (Amyotrophic Lateral Sclerosis)

Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1

Amyotrophic Lateral Sclerosis With Dementia

Amyotrophic Lateral Sclerosis, Guam Form

Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam

Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1

Charcot Disease

Dementia With Amyotrophic Lateral Sclerosis

Disease, Guam

Disease, Lou-Gehrigs

Gehrig Disease

Gehrig's Disease

Gehrigs Disease

Guam Disease

Guam Form of Amyotrophic Lateral Sclerosis

Lou Gehrig Disease

Lou Gehrig's Disease

Lou-Gehrigs Disease

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Amyotrophic Lateral

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)