Antigens, CD95
Synonyms
APO 1 Antigen
APO-1 Antigen
CD95 Antigen
CD95 Antigens
Fas Cell Surface Death Receptor
Receptor, TNFRSF6
Receptor, fas
Receptors, fas
TNFRSF6 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 6
fas Antigen
fas Antigens
fas Receptor
fas Receptors
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.