Apolipoprotein E4


Apo E 4

Apo E epsilon 4

Apo E-4

Apo E4


Apolipoprotein E 4

Apolipoprotein E-4

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.