Glucose-6-Phosphate Isomerase


Autocrine Motility Factor

D-Glucose-6-phosphate ketol-isomerase

Glucose 6 Phosphate Isomerase

Glucosephosphate Isomerase

Isomerase, Glucose 6 Phosphate

Isomerase, Glucose-6-Phosphate

Isomerase, Glucosephosphate

Isomerase, Phosphoglucose

Isomerase, Phosphohexose

Motility Factor, Autocrine


Phosphoglucose Isomerase

Phosphohexose Isomerase

Tumor Autocrine Motility Factor

Tumor Cell Autocrine Motility Factor

Tumor-Cell Autocrine Motility Factor

An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.