Granulocyte-Macrophage Colony-Stimulating Factor

Synonyms

CSF-2

CSF-GM

Cell-Stimulating Factor, Histamine-Producing

Colony Stimulating Factor, Granulocyte Macrophage

Colony-Stimulating Factor, Granulocyte-Macrophage

Colony-stimulating factor 2

GM-CSF

Granulocyte Macrophage Colony Stimulating Factor

Histamine Producing Cell Stimulating Factor

Histamine-Producing Cell-Stimulating Factor

TC-GM-CSF

Tumor Cell Human GM Colony Stimulating Factor

Tumor-Cell Human GM Colony-Stimulating Factor

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.