Nomifensine

Synonyms

8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-

Hoe 984

Hoe-984

Hoe984

Linamiphen

Maleate, Nomifensine

Merital

Nomifensin

Nomifensine Maleate

Nomifensine Maleate (1:1)

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)