Optic Atrophy, Hereditary, Leber

Synonyms

Disease, Leber's

Diseases, Leber's

Hereditary Optic Neuroretinopathies

Hereditary Optic Neuroretinopathy

Leber Disease

Leber Hereditary Optic Atrophy

Leber Hereditary Optic Neuropathy

Leber Optic Atrophy

Leber Optic Atrophy and Dystonia

Leber Optic Neuropathy

Leber's Disease

Leber's Diseases

Leber's Hereditary Optic Atrophy

Leber's Hereditary Optic Neuropathy

Leber's Optic Atrophy

Leber's Optic Neuropathy

Lebers Disease

Lebers Optic Neuropathy

Neuropathy, Leber's Optic

Neuroretinopathies, Hereditary Optic

Neuroretinopathy, Hereditary Optic

Optic Atrophy, Leber

Optic Atrophy, Leber Type

Optic Atrophy, Leber, Hereditary

Optic Neuropathy, Leber's

Optic Neuroretinopathies, Hereditary

Optic Neuroretinopathy, Hereditary

A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))