Pleckstrin Homology Domains


Domain, PH

Domain, Pleckstrin Homology

Domains, PH

Domains, Pleckstrin Homology

Homology Domain, Pleckstrin

Homology Domains, Pleckstrin

PH Domain

PH Domains

Pleckstrin Homology Domain

Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.