Signaling Lymphocytic Activation Molecule Family
Synonyms
SLAM Family Receptors
SLAMF Receptors
Signaling Lymphocytic Activation Molecule Family Receptors
Signaling Lymphocytic Activation Molecule Receptors
Signaling Lymphocytic Activation Molecules
Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.