Src Homology 2 Domain-Containing, Transforming Protein 1


SHC (Src Homology 2 Domain-Containing) Transforming Protein 1

SHC Transforming Protein 1

SHC-Transforming Protein 1

SHC1 (Src Homology 2 Domain-Containing) Protein

SHC1 Protein

ShcA Protein

Src Homology 2 Domain Containing Transforming Protein C1

Src Homology 2 Domain Containing, Transforming Protein 1

Src Homology 2 Domain-Containing-Transforming Protein C1

An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.