Classical Lissencephalies and Subcortical Band Heterotopias


Agyria Pachygyria Band Spectrum

Agyria-Pachygyria-Band Spectrum

Band Heterotopia, Lissencephaly-Subcortical

Chromosome 17p13.3 Deletion Syndrome

Classic Lissencephaly

Classical Lissencephalies

Classical Lissencephaly

Classical Lissencephaly Syndrome

Double Cortex Syndrome

Heterotopia, Lissencephaly-Subcortical Band

Heterotopia, Subcortical Band

Heterotopia, Subcortical Laminar

Heterotopias, Lissencephaly-Subcortical Band

Heterotopias, Subcortical Band

Heterotopias, Subcortical Laminar

Isolated Lissencephaly Sequence

Lissencephalies, Classical

Lissencephalies, Type 1

Lissencephalies, X-Linked

Lissencephaly 1

Lissencephaly Sequence, Isolated

Lissencephaly Subcortical Band Heterotopia

Lissencephaly Syndrome, Miller Dieker

Lissencephaly Syndrome, Miller-Dieker

Lissencephaly Type 1

Lissencephaly, Classic

Lissencephaly, Classical

Lissencephaly, Miller Dieker

Lissencephaly, Miller-Dieker

Lissencephaly, Type 1

Lissencephaly, X Linked

Lissencephaly, X-Linked

Lissencephaly, X-Linked, 1

Lissencephaly-Subcortical Band Heterotopia

Lissencephaly-Subcortical Band Heterotopias

Miller Dieker Lissencephaly Syndrome

Miller Dieker Syndrome

Miller-Dieker Lissencephaly

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Subcortical Band Heterotopia

Subcortical Band Heterotopias

Subcortical Laminar Heterotopia

Syndrome, Double Cortex

Syndrome, Miller-Dieker

Syndrome, Miller-Dieker Lissencephaly

Type 1 Lissencephalies

Type 1 Lissencephaly

X Linked Lissencephaly

X-Linked Lissencephalies

X-Linked Lissencephaly

Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)