Cyclic Nucleotide Phosphodiesterases, Type 2


3',5'-Cyclic Phosphodiesterase, cGMP-Dependent

Cyclic GMP Stimulated Phosphodiesterase

Cyclic GMP-Stimulated Phosphodiesterase

Cyclic Nucleotide Phosphodiesterase PDE2 Family

Cyclic Nucleotide Phosphodiesterases, Type 2A

PDE2 Phosphodiesterase

PDE2 Phosphodiesterases

Phosphodiesterase 2A

Phosphodiesterase, Cyclic GMP-Stimulated

cGMP Dependent 3',5' Cyclic Phosphodiesterase

cGMP-Dependent 3',5'-Cyclic Phosphodiesterase

A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC, members of this class have additional specificity for CYCLIC GMP.