Cytochrome P-450 Enzyme System


CYP450 Family

CYP450 Superfamily

Cytochrome P 450

Cytochrome P 450 Dependent Monooxygenase

Cytochrome P 450 Enzyme System

Cytochrome P 450 Enzymes

Cytochrome P 450 Families

Cytochrome P 450 Monooxygenase

Cytochrome P 450 Oxygenase

Cytochrome P 450 Superfamily

Cytochrome P-450

Cytochrome P-450 Enzymes

Cytochrome P-450 Families

Cytochrome P-450 Monooxygenase

Cytochrome P-450 Oxygenase

Cytochrome P-450 Superfamily

Cytochrome P-450-Dependent Monooxygenase

Cytochrome P450

Cytochrome P450 Superfamily

Cytochrome p450 Families

Enzymes, Cytochrome P-450

Enzymes, P-450

Enzymes, P450

Monooxygenase, Cytochrome P-450

Monooxygenase, Cytochrome P-450-Dependent

P 450 Enzymes

P-450 Enzymes

P-450 Enzymes, Cytochrome

P450 Enzymes

Superfamily, CYP450

Superfamily, Cytochrome P-450

Superfamily, Cytochrome P450

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.