Factor XIIa


Activated Factor XII

Activator, Prekallikrein

Blood Coagulation Factor XII, Activated

Coagulation Factor XIIa

Factor XII, Activated

Factor XIIa, Coagulation

Fragments, Hageman-Factor

Hageman Factor Fragments

Hageman-Factor Fragments

Prekallikrein Activator

XIIa, Coagulation Factor

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

See Also