Kininogen, High-Molecular-Weight


Fitzgerald Factor


High Molecular Weight Kininogen

High Molecular Weight Kininogens

High-Molecular-Weight Kininogen

High-Molecular-Weight Kininogens

Kininogen, High Molecular Weight

Kininogens, High Molecular Weight

Kininogens, High-Molecular-Weight

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)