N-Myc Proto-Oncogene Protein


BHLHE37 Protein

Class E Basic Helix Loop Helix Protein 37

Class E Basic Helix-Loop-Helix Protein 37

MYCN Protein

N Myc Protein

N Myc Proto Oncogene Protein

N-Myc Protein

NMYC Protein

Proto-Oncogene Protein, N-Myc

A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.