Insulin Receptor Protein Tyrosine Kinase
Insulin Receptor Protein-Tyrosine Kinase
Insulin Receptor alpha Chain
Insulin Receptor alpha Subunit
Insulin Receptor beta Chain
Insulin Receptor beta Subunit
Insulin-Dependent Tyrosine Protein Kinase
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.